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ORIGINAL RESEARCH article

Front. Hum. Neurosci.
Sec. Brain Health and Clinical Neuroscience
Volume 18 - 2024 | doi: 10.3389/fnhum.2024.1411849
This article is part of the Research Topic Women in Brain Health and Clinical Neuroscience Volume II: 2023 View all articles

Single-domain magnetic particles with motion behavior under electromagnetic AC and DC fields are a fatal cargo in Metropolitan Mexico City pediatric and young adult early Alzheimer, Parkinson, Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis and in ALS patients

Provisionally accepted
Lilian Calderon-Garciduenas Lilian Calderon-Garciduenas 1*Ruben Cejudo-Ruiz Ruben Cejudo-Ruiz 2Elijah W. Stommel Elijah W. Stommel 3ANGELICA G. MACIEL ANGELICA G. MACIEL 4RAFAEL R. ROBLES RAFAEL R. ROBLES 4Ricardo Torres-Jardon Ricardo Torres-Jardon 2Samuel Tehuacanero-Cuapa Samuel Tehuacanero-Cuapa 2Arturo Rodríguez-Gómez Arturo Rodríguez-Gómez 2Francisco Bautista Francisco Bautista 2Avtandyl Goguitchaichvili Avtandyl Goguitchaichvili 2Beatriz Perez-Guille Beatriz Perez-Guille 4Rosa Eugenia Soriano-Rosales Rosa Eugenia Soriano-Rosales 4Emel Koseoglu Emel Koseoglu 5Partha Sarathi Mukherjee Partha Sarathi Mukherjee 6
  • 1 Biomedical Sciences, University of Montana, Missoula, Montana, United States
  • 2 National Autonomous University of Mexico, México City, México, Mexico
  • 3 Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States
  • 4 National Institute of Pediatrics (Mexico), Mexico City, México, Mexico
  • 5 Faculty of Medicine, Erciyes University, Kayseri, Türkiye
  • 6 Human Genetics Unit, Indian Statistical Institute, Kolkata, Kolkata, West Bengal, India

The final, formatted version of the article will be published soon.

    Metropolitan Mexico City (MMC) children and young adults exhibit overlapping Alzheimer and Parkinsons’ diseases (AD, PD) and TAR DNA-binding protein 43 pathology with magnetic ultrafine particulate matter (UFPM) and industrial nanoparticles (NPs). We studied magnetophoresis, electron microscopy and energy-dispersive X-ray spectrometry in 203 brain samples from 14 children, 27 adults and 27 ALS cases/controls. Saturation isothermal remanent magnetization (SIRM), capturing magnetically unstable FeNPs ̴ 20nm, was higher in caudate, thalamus, hippocampus, putamen, and motor regions with subcortical vs cortical higher SIRM in MMC ≤ 40y. Motion behavior was associated with magnetic exposures 25-100 mT and children exhibited IRM saturated curves at 50-300 mT associated to change in NPs position and/or orientation in situ. Targeted magnetic profiles moving under AC/AD magnetic fields could distinguish ALS vs controls. Motor neuron magnetic NPs accumulation potentially interferes with action potentials, ion channels, nuclear pores and enhances the membrane insertion process when coated with lipopolysaccharides. TEM and EDX showed 7-20 nm NP Fe, Ti, Co, Ni, V, Hg, W, Al, Zn, Ag, Si, S, Br, Ce, La and Pr in abnormal neural and vascular organelles. Brain accumulation of magnetic unstable particles start in childhood and cytotoxic, hyperthermia, free radical formation, and NPs motion associated to 30-50 µT (DC magnetic fields) are critical given ubiquitous electric and magnetic fields exposures could induce motion behavior and neural damage. Magnetic UFPM/NPs are a fatal brain cargo in children’s brains, and a preventable AD, PD, FTLD, ALS environmental threat. Billions of people are at risk. We are clearly poisoning ourselves.

    Keywords: brain magnetic nanoparticles, saturation isothermal remanent magnetization SIRM, pediatric Alzheimer, single domain FeNPs, Motion nanaoparticle behavior, Alzheimer, Parkinson, Frontotemporal Lobar Degeneration

    Received: 03 Apr 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Calderon-Garciduenas, Cejudo-Ruiz, Stommel, MACIEL, ROBLES, Torres-Jardon, Tehuacanero-Cuapa, Rodríguez-Gómez, Bautista, Goguitchaichvili, Perez-Guille, Soriano-Rosales, Koseoglu and Mukherjee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lilian Calderon-Garciduenas, Biomedical Sciences, University of Montana, Missoula, 59812, Montana, United States

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