AUTHOR=Rivas-Fernández Miguel Ángel , Lindín Mónica , Zurrón Montserrat , Díaz Fernando , Aldrey-Vázquez José Manuel , Pías-Peleteiro Juan Manuel , Vázquez-Vázquez Laura , Pereiro Arturo Xosé , Lojo-Seoane Cristina , Nieto-Vieites Ana , Galdo-Álvarez Santiago 

TITLE=Brain Atrophy and Clinical Characterization of Adults With Mild Cognitive Impairment and Different Cerebrospinal Fluid Biomarker Profiles According to the AT(N) Research Framework of Alzheimer’s Disease

JOURNAL=Frontiers in Human Neuroscience

VOLUME=16

YEAR=2022

URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2022.799347

DOI=10.3389/fnhum.2022.799347

ISSN=1662-5161

ABSTRACT=<sec><title>Introduction</title><p>This study aimed to evaluate, in adults with mild cognitive impairment (MCI), the brain atrophy that may distinguish between three AT(N) biomarker-based profiles, and to determine its clinical value.</p></sec><sec><title>Methods</title><p>Structural MRI (sMRI) was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT(N) profiles, namely, A−T−(N)−: <italic>normal AD biomarkers</italic>; A+T−(N)−: <italic>AD pathologic change</italic>; and A+T+(N)+: <italic>prodromal AD</italic>. Sensitivity and specificity of these changes were also estimated.</p></sec><sec><title>Results</title><p>An initial atrophy in medial temporal lobe (MTL) areas was found in the A+T−(N)− and A+T+(N)+ groups, spreading toward the parietal and frontal regions in A+T+(N)+ patients. These structural changes allowed distinguishing AT(N) profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.</p></sec><sec><title>Conclusion</title><p>sMRI is useful in the determination of the specific brain structural changes of AT(N) profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers.</p></sec>