AUTHOR=Balzekas Irena , Sladky Vladimir , Nejedly Petr , Brinkmann Benjamin H. , Crepeau Daniel , Mivalt Filip , Gregg Nicholas M. , Pal Attia Tal , Marks Victoria S. , Wheeler Lydia , Riccelli Tori E. , Staab Jeffrey P. , Lundstrom Brian Nils , Miller Kai J. , Van Gompel Jamie , Kremen Vaclav , Croarkin Paul E. , Worrell Gregory A. TITLE=Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies JOURNAL=Frontiers in Human Neuroscience VOLUME=15 YEAR=2021 URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2021.702605 DOI=10.3389/fnhum.2021.702605 ISSN=1662-5161 ABSTRACT=

Intracranial electroencephalographic (iEEG) recordings from patients with epilepsy provide distinct opportunities and novel data for the study of co-occurring psychiatric disorders. Comorbid psychiatric disorders are very common in drug-resistant epilepsy and their added complexity warrants careful consideration. In this review, we first discuss psychiatric comorbidities and symptoms in patients with epilepsy. We describe how epilepsy can potentially impact patient presentation and how these factors can be addressed in the experimental designs of studies focused on the electrophysiologic correlates of mood. Second, we review emerging technologies to integrate long-term iEEG recording with dense behavioral tracking in naturalistic environments. Third, we explore questions on how best to address the intersection between epilepsy and psychiatric comorbidities. Advances in ambulatory iEEG and long-term behavioral monitoring technologies will be instrumental in studying the intersection of seizures, epilepsy, psychiatric comorbidities, and their underlying circuitry.