AUTHOR=Zhang Yun , Yan Fei , Wang Liu , Wang Yubo , Wang Chunshu , Wang Qiang , Huang Liyu TITLE=Cortical Areas Associated With Mismatch Negativity: A Connectivity Study Using Propofol Anesthesia JOURNAL=Frontiers in Human Neuroscience VOLUME=12 YEAR=2018 URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2018.00392 DOI=10.3389/fnhum.2018.00392 ISSN=1662-5161 ABSTRACT=

Auditory mismatch negativity (MMN) is an event-related potential (ERP) waveform induced by rare deviant stimuli that occur in a stream of regular auditory stimuli. The generators of MMN are believed to include several different cortical regions like the bilateral temporal and the right inferior frontal gyrus (IFG). However, exact cortical regions associated with MMN remain controversial. In this study, we compared the number of long-distance connections induced by the standard and deviant stimuli during awake state and propofol anesthesia state to identify the cortical areas associated with the generation of MMN. In awake state, we find that deviant stimuli synchronize more information between the right frontal and temporal than standard stimuli. Moreover, we find that the deviant stimuli in awake state activate the bilateral frontal, central areas, the left temporal and parietal areas as compared to the anesthesia state, whereas the standard stimuli do not. These results suggest that, in addition to the bilateral temporal and the right IFG, the bilateral frontal and centro-parietal regions also contribute to the generation of MMN.