AUTHOR=Naro Antonino , Milardi Demetrio , Russo Margherita , Terranova Carmen , Rizzo Vincenzo , Cacciola Alberto , Marino Silvia , Calabro Rocco S. , Quartarone Angelo 

TITLE=Non-invasive Brain Stimulation, a Tool to Revert Maladaptive Plasticity in Neuropathic Pain

JOURNAL=Frontiers in Human Neuroscience

VOLUME=10

YEAR=2016

URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2016.00376

DOI=10.3389/fnhum.2016.00376

ISSN=1662-5161

ABSTRACT=<p>Neuromodulatory effects of non-invasive brain stimulation (NIBS) have been extensively studied in chronic pain. A hypothetic mechanism of action would be to prevent or revert the ongoing maladaptive plasticity within the pain matrix. In this review, the authors discuss the mechanisms underlying the development of maladaptive plasticity in patients with chronic pain and the putative mechanisms of NIBS in modulating synaptic plasticity in neuropathic pain conditions.</p>