AUTHOR=Duan Mingjun , Chen Xi , He Hui , Jiang Yuchao , Jiang Sisi , Xie Qiankun , Lai Yongxiu , Luo Cheng , Yao Dezhong 

TITLE=Altered Basal Ganglia Network Integration in Schizophrenia

JOURNAL=Frontiers in Human Neuroscience

VOLUME=9

YEAR=2015

URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2015.00561

DOI=10.3389/fnhum.2015.00561

ISSN=1662-5161

ABSTRACT=<p>The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilateral caudate nucleus in schizophrenia patients. Further, the caudate nucleus in patients showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia patients. <italic>Clinical Trial Registration:</italic> Chinese Clinical Trial Registry. Registration number ChiCTR-RCS-14004878.</p>