AUTHOR=Yin Hong , Tully Laura M. , Lincoln Sarah Hope , Hooker Christine I. 

TITLE=Adults with high social anhedonia have altered neural connectivity with ventral lateral prefrontal cortex when processing positive social signals

JOURNAL=Frontiers in Human Neuroscience

VOLUME=Volume 9 - 2015

YEAR=2015

URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2015.00469

DOI=10.3389/fnhum.2015.00469

ISSN=1662-5161

ABSTRACT=Social anhedonia (SA) is a debilitating characteristic of schizophrenia and a vulnerability for developing schizophrenia among people at risk.  Prior work (Hooker et al, 2014) has revealed neural deficits in ventral lateral prefrontal cortex (VLPFC) during processing of positive emotion in a community sample of people with high social anhedonia.  Deficits in VLPFC neural activity are related to worse self-reported schizophrenia-spectrum symptoms and worse mood and behavior after social stress.  In the current study, psychophysiological interaction (PPI) analysis was applied to investigate the neural mechanisms mediated by VLPFC during emotion processing.  PPI analysis revealed that, compared to low SA controls, participants with high SA displayed reduced VLPFC integration, specifically reduced connectivity between VLPFC and premotor cortex, inferior parietal and posterior temporal regions when viewing positive relative to neutral emotion.  Across all participants, connectivity between VLPFC and inferior parietal region when viewing positive (versus neutral) emotion was significantly correlated with measures of emotion management and attentional control.  Additionally connectivity between VLPFC and superior temporal sulcus was related to reward and pleasure anticipation, and connectivity between VLPFC and inferior temporal sulcus correlated with attentional control measure.  Our results suggest that impairments to VLPFC mediated neural circuitry underlie the cognitive and emotional deficits.