AUTHOR=Mihulowicz Urszula , Willmes Klaus , Karnath Hans-Otto , Klein Elise 

TITLE=Single-digit arithmetic processing—anatomical evidence from statistical voxel-based lesion analysis

JOURNAL=Frontiers in Human Neuroscience

VOLUME=8

YEAR=2014

URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2014.00286

DOI=10.3389/fnhum.2014.00286

ISSN=1662-5161

ABSTRACT=<p>Different specific mechanisms have been suggested for solving single-digit arithmetic operations. However, the neural correlates underlying basic arithmetic (multiplication, addition, subtraction) are still under debate. In the present study, we systematically assessed single-digit arithmetic in a group of acute stroke patients (<italic>n</italic> = 45) with circumscribed left- or right-hemispheric brain lesions. Lesion sites significantly related to impaired performance were found only in the left-hemisphere damaged (LHD) group. Deficits in multiplication and addition were related to subcortical/white matter brain regions differing from those for subtraction tasks, corroborating the notion of distinct processing pathways for different arithmetic tasks. Additionally, our results further point to the importance of investigating fiber pathways in numerical cognition.</p>