ORIGINAL RESEARCH article
Front. Hematol.
Sec. Red Cells, Iron and Erythropoiesis
Volume 4 - 2025 | doi: 10.3389/frhem.2025.1560766
Trends in hemolytic anemia-related mortality in the United States from 1999-2022
Provisionally accepted
- 1School of Medicine, Creighton University, Omaha, United States
- 2Creighton University Department of Internal Medicine, Omaha, United States
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Background: Anemia carries the third highest years lived with disability, and yet the subset of hemolytic anemia is associated with higher rates of mortality and complication than other types of anemia. There is a lack of data studying the more encompassing subset of hemolytic anemia mortality at a population level.Methods: In this study, we analyzed the temporal trends of demographic and geographical differences in hemolytic anemia-related mortality in the United States from 1999-2022. Data was extruded from the CDC Wide-Ranging Online Data for Epidemiologic Research (WONDER) database. Crude mortality rates, age-adjusted mortality rates (AAMR), annual percent change (APC), and average annual percent change (AAPC) were determined with 95% confidence intervals (CIs) using the Joinpoint Regression Program.Results: From 1999-2022, there were 46,924 deaths due to hemolytic anemia. Mortality rates decreased significantly from 1999-2016 before increasing significantly from 2016-2022. Mortality rates were higher in males, Black or African American people, and urban areas. Interestingly, all groups showed a similar increase in mortality rates in recent years except for people aged 15-24 years who showed consistently decreasing mortality over the study period.Conclusion: Hemolytic anemia-related mortality in the United States decreased overall between 1999 and 2022. While a decrease was seen between 1999 and 2016, an increase was seen starting from 2016, most prominently from 2019 to 2021 in most of the subgroups with males, African American and the south region having the worst AAMRs.
Keywords: hemolytic anemia, CDC WONDER, Mortality, Sickle Cell Disease, Anemia
Received: 14 Jan 2025; Accepted: 24 Apr 2025.
Copyright: © 2025 Tuin, Diehl, Billion, Mirza, Tauseef and Abdul Jabbar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ashley Tuin, School of Medicine, Creighton University, Omaha, United States
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