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REVIEW article
Front. Hematol.
Sec. Blood Cancer
Volume 4 - 2025 | doi: 10.3389/frhem.2025.1435193
Abnormalities of the primary and secondary hemostasis in multiple myeloma: insights from studies on thrombopoiesis, coagulation system, and bone marrow microenvironment
Provisionally accepted- California State University, Dominguez Hills, Carson, United States
In multiple myeloma (MM), hemostatic disorders such as thrombocytopenia, coagulopathies, and thrombophilia are well-documented. These abnormalities can be partially attributed to therapy, including thrombocytopenia following treatment with proteasome inhibitors like bortezomib and carfilzomib, or thrombosis associated with immunomodulatory drugs such as thalidomide and lenalidomide. However, acquired hemostatic disorders have also been observed in untreated or newly diagnosed MM patients. This review explores these abnormalities in both treated and untreated contexts, presenting recent studies that provide new insights into the mechanisms underlying these complications. It highlights the role of the bone marrow microenvironment, particularly mesenchymal stromal cells (MSCs) and extracellular vesicles (EVs). Additionally, the review discusses future research directions on hemostatic disorders, including bleeding and thrombosis, in MM patients. Overall, this review aims to be a valuable resource for scientists and clinicians in the field.
Keywords: Multiple Myeloma, coagulopathy, bone marrow mesenchymal stromal cells, Bleeding diathesis, Thrombosis
Received: 19 May 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Abdi and Nasr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jahan Abdi, California State University, Dominguez Hills, Carson, United States
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