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CASE REPORT article

Front. Hematol.
Sec. Hematopoiesis and Stem Cells
Volume 3 - 2024 | doi: 10.3389/frhem.2024.1435584
This article is part of the Research Topic Women in Hematopoiesis and Stem Cells View all 4 articles

Late Onset Pancytopenia Post Chimeric Antigen Receptor (CAR)-T Therapy Triggered by COVID-19 Vaccination: a Case Report.

Provisionally accepted
Nicola Maciocia Nicola Maciocia 1,2*Dean Spencer Dean Spencer 2Paul Maciocia Paul Maciocia 1,2Anna Childerhouse Anna Childerhouse 2Maeve O'Reilly Maeve O'Reilly 2Elspeth Payne Elspeth Payne 1,2Claire Roddie Claire Roddie 1,2
  • 1 University College London, London, United Kingdom
  • 2 University College Hospital (UCH), London, England, United Kingdom

The final, formatted version of the article will be published soon.

    Cytopenias are a common side effect after CAR-T cell therapy but are unusual at late timepoints when they are most commonly due to BM failure, myelodysplasia (MDS) or other secondary malig-nancies. In this case report we describe a patient who developed severe aplastic anaemia 18 months after CD19 CAR-T therapy, and shortly after COVID-19 vaccination. This is the first description of severe aplastic anaemia triggered by COVID-19 vaccination as a cause of post CAR-T cytopenias. The patient described was treated with combination eltrombopag and ciclosporin due to frailty and made a rapid and complete clinical response to this therapy, providing an effective option for treat-ment of immune related cytopenias post CAR-T in an increasingly elderly and frail treated popula-tion.

    Keywords: Late Onset Pancytopenia Post Chimeric Antigen Receptor (CAR)-T Therapy Triggered by COVID-19 Vaccination: a Case Report Case report, COVID-19, CAR-T cell, Aplastic anaemia, eltrombopag

    Received: 20 May 2024; Accepted: 17 Oct 2024.

    Copyright: © 2024 Maciocia, Spencer, Maciocia, Childerhouse, O'Reilly, Payne and Roddie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nicola Maciocia, University College London, London, United Kingdom

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