AUTHOR=Jin Yingming , Ren Fupeng , Wang Shuyan , Xu Jin , Wu Yingying , Tang Jinfen , Xu Jianfen 

TITLE=Case Report: A rare case of CD20-positive T-cell large granular lymphocyte leukemia with renal cell carcinoma: a challenging diagnosis

JOURNAL=Frontiers in Hematology

VOLUME=2

YEAR=2023

URL=https://www.frontiersin.org/journals/hematology/articles/10.3389/frhem.2023.1160049

DOI=10.3389/frhem.2023.1160049

ISSN=2813-3935

ABSTRACT=<p>Large granular lymphocytic leukemia (LGLL) is a clonal lymphoproliferative disease with a slow course and considerable difficulties in correct diagnosis and therapy. T-LGLL is the most prevalent subtype of LGLL, accounting for approximately 85%. T-LGLL co-existence with solid malignancies is relatively rare. CD20-positive T-cell neoplasm is a rare disease in clinics. In this study, we report a case of CD20-positive T-LGLL with renal cell carcinoma (RCC) that was eventually diagnosed by splenectomy and nephrectomy. The accumulation of cases will contribute to diagnosing and treating CD20-positive T-LGLL complicated with solid tumors.</p>