AUTHOR=Omar Said Z. , Haverkate Nienke J. E. , van Hoeven Vera , Blom Bianca , Hazenberg Mette D. TITLE=Drug exporter expression correlates with group 3 innate lymphoid cell resistance to immunosuppressive agents JOURNAL=Frontiers in Hematology VOLUME=2 YEAR=2023 URL=https://www.frontiersin.org/journals/hematology/articles/10.3389/frhem.2023.1144418 DOI=10.3389/frhem.2023.1144418 ISSN=2813-3935 ABSTRACT=
Allogeneic hematopoietic cell transplantation (HCT) is often complicated by graft versus host disease (GvHD), an alloreactive immune response triggered by tissue damage. Interleukin (IL)-22 producing type 3 innate lymphoid cells (ILC3) protect epithelial tissues against chemo(radio)therapy-induced damage, suppress alloreactive T cells and mitigate acute GvHD symptoms after allogeneic HCT. Relatively high numbers of ILC before and after allogeneic HCT has been associated with significantly reduced tissue damage and less acute GvHD. While most transplantation conditioning and GvHD prophylaxis regimens are aimed at eliminating host and alloreactive donor lymphocytes, the effect of these regimens on ILC remain elusive. Here, we studied the effect of conditioning chemotherapy and immunosuppressive agents on the survival, proliferation, activation and function of human ILC3