AUTHOR=Hlaing Swe Swe , Kurian Christine Jane , Tan Jennie , Behling Eric , Hussein Ahmed Kamel Abou 

TITLE=Case Report: A unique case of secondary hemophagocytic lymphohistiocytosis from ehrlichiosis infection

JOURNAL=Frontiers in Hematology

VOLUME=1

YEAR=2022

URL=https://www.frontiersin.org/journals/hematology/articles/10.3389/frhem.2022.1039821

DOI=10.3389/frhem.2022.1039821

ISSN=2813-3935

ABSTRACT=<p>Hemophagocytic lymphohistiocytosis (HLH) is a highly detrimental syndrome that can progress to multiorgan failure, necessitating the resources of an intensive care unit, with a mortality rate as high as 40%. Secondary HLH is usually triggered by infection, most often from a viral infection or malignancy. Management of HLH in adults is challenging as treatment algorithms targeting hyperinflammation are based on pediatric protocols, such as HLH-94 and HLH-2004. To our knowledge, there are only a few reported cases of HLH secondary to ehrlichiosis infection and none in elderly patients with multiple comorbidities. Here, we present a unique case of HLH secondary to ehrlichiosis infection in an 82-year-old female successfully treated with antibiotics and steroids.</p>