AUTHOR=Wang Yihan , Hon Gary C. 

TITLE=Towards functional maps of non-coding variants in cancer

JOURNAL=Frontiers in Genome Editing

VOLUME=6

YEAR=2024

URL=https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2024.1481443

DOI=10.3389/fgeed.2024.1481443

ISSN=2673-3439

ABSTRACT=<p>Large scale cancer genomic studies in patients have unveiled millions of non-coding variants. While a handful have been shown to drive cancer development, the vast majority have unknown function. This review describes the challenges of functionally annotating non-coding cancer variants and understanding how they contribute to cancer. We summarize recently developed high-throughput technologies to address these challenges. Finally, we outline future prospects for non-coding cancer genetics to help catalyze personalized cancer therapy.</p>