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REVIEW article
Front. Genet.
Sec. RNA
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1561799
Regulatory Mechanisms of m6A RNA Methylation in Esophageal Cancer: A Comprehensive Review
Provisionally accepted- 1Department of Thoracic Surgery, Suining Central Hospital, Suining, China
- 2North Sichuan Medical College, Nanchong, Sichuan Province, China
- 3Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 4Suining Central Hospital, Suining, China
- 5Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China
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Esophageal cancer is an aggressively malignant neoplasm characterized by a high mortality rate.Frequently diagnosed at an advanced stage, it presents challenges for optimal therapeutic intervention due to its non-specific symptoms, resulting in lost opportunities for effective treatment, such as surgery, radiotherapy, chemotherapy and target therapy. The N6-methyladenosine (m6A) modification represents the most critical post-transcriptional modification of eukaryotic messenger RNA (mRNA). The reversible m6A modification is mediated by three regulatory factors: m6A methyltransferases, demethylating enzymes, and m6A recognition proteins. These components identify and bind to specific RNA methylation sites, thereby modulating essential biological functions such as RNA processing, nuclear export, stability, translation and degradation, which significantly influence tumorigenesis, invasion, and metastasis. Given the importance of m6A modification, this paper offers a comprehensive examination of the regulatory mechanisms, biological functions, and future therapeutic implications of m6A RNA methylation in the context of esophageal cancer.
Keywords: esophageal cancer, RNA modification, N6-Methyladenosine, occurrence, Treatment
Received: 22 Jan 2025; Accepted: 07 Apr 2025.
Copyright: © 2025 Wen, Fu, Wang, Xie, Tang, Yu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Li Yu, Suining Central Hospital, Suining, 629000, China
Haining Zhou, Department of Thoracic Surgery, Suining Central Hospital, Suining, 629000, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.