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REVIEW article
Front. Genet.
Sec. Applied Genetic Epidemiology
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1560276
This article is part of the Research Topic Insights in Applied Genetic Epidemiology 2025 View all articles
Number of words: 5512 Number of figures: 2 Number of table: 4 Sex Differences in Asthma: Omics Evidence and Future Directions
Provisionally accepted
Bichen Peng 1
Weiyi Ye 1* Shuai Lui 2* Yue Jiang 1*
Ziang Meng 1
Miao Guo 1*
Lili Zhi 3* Xiao Chang 1*
Lei Shao 4*- 1 Shandong First Medical University, Tai'an, China
- 2 Agricultural Products Quality and Safety Center of Ji'nan, Jinan, China
- 3 Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China
- 4 Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China
Asthma is a common and complex heterogeneous disease, with prevalence and severity varying across different age groups and sexes. Over the past few decades, with the development of high-throughput technologies, various "omics" analyses have emerged and been applied to asthma research, providing us with significant opportunities to study the genetic mechanisms underlying asthma. However, despite these advancements, the differences and specificities in the genetic mechanisms of asthma between sexes remain to be fully explored. Moreover, clinical guidelines have yet to incorporate or recommend sex-specific asthma management based on high-quality omics evidence. In this article, we review recent omics-level findings on sex differences in asthma and discuss how to better integrate these multidimensional findings to generate further insights and advance the precision and effectiveness of asthma treatment.
Keywords: Asthma, sex differences, multi-omics, Genomics, Transcriptomics, Epigenomics, Proteomics, Metabolomics
Received: 14 Jan 2025; Accepted: 11 Feb 2025.
Copyright: © 2025 Peng, Ye, Lui, Jiang, Meng, Guo, Zhi, Chang and Shao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weiyi Ye, Shandong First Medical University, Tai'an, China
Shuai Lui, Agricultural Products Quality and Safety Center of Ji'nan, Jinan, China
Yue Jiang, Shandong First Medical University, Tai'an, China
Miao Guo, Shandong First Medical University, Tai'an, China
Lili Zhi, Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong Province, China
Xiao Chang, Shandong First Medical University, Tai'an, China
Lei Shao, Central Hospital Affiliated to Shandong First Medical University, Jinan, 271000, Shandong Province, China
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