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ORIGINAL RESEARCH article
Front. Genet.
Sec. Computational Genomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1554116
This article is part of the Research Topic Computational Approaches Integrate Multi-Omics Data for Disease Diagnosis and Treatment View all 6 articles
Liver Failure Diagnosis: Key Diagnostic Biomarkers Discovery and Bioinformatic Validation
Provisionally accepted- 1 Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
- 2 Clinical Laboratory Department, Affiliated Tongji University East Hospital Jiaozhou Hospital, jiaozhou, China
- 3 Tongji University affilated EAST Hospital Jiaozhou hospital, Jiaozhou city, China
- 4 tongji university affilated East Hosptal Jiaozhou hospital, jiaozhou, China
- 5 tongji univerty, jiaozhoucity, China
- 6 tongji univerty, Qingdaocity, China
- 7 Department of liver disease，Shandong University, jinan, China
Glutathione peroxidase 3 (GPX3) is a strong antioxidant. While elevated GPX3 levels are linked to diverse pathologies, its role in liver failure (LF) remains underexplored.This study investigates GPX3's diagnostic potential and mechanistic contributions to LF pathogenesis.We integrated two high-quality liver tissue datasets (GSE38941 and GSE14668) from the Gene Expression Omnibus (GEO) database. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were conducted to identify potentialIn conclusion, GPX3 is a promising diagnostic biomarker for liver failure. Its promoter methylation status may serve as a prognostic indicator, highlighting its therapeutic potential.
Keywords: Glutathione peroxidase 3, hepatic failure, Immune Cell Infiltration, promoter methylation, Diagnostic biomarker
Received: 01 Jan 2025; Accepted: 17 Mar 2025.
Copyright: © 2025 Ye, Wang and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hong Ye, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
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