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ORIGINAL RESEARCH article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1549602
This article is part of the Research Topic Genetic and Immunological Insights in Solid Tumors: Comprehensive Approaches to Treatment View all 4 articles
Retrospective Analysis of Inflammatory Biomarkers and Prognosis in Non-Small Cell Lung Cancer Without Adenocarcinoma In Situ
Provisionally accepted- Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Background: Inflammatory biomarkers have shown prognostic value in Non-Small Cell Lung Cancer (NSCLC), but the inclusion of Adenocarcinoma In Situ (AIS) cases in previous studies may introduce bias. This study aims to evaluate the prognostic significance of inflammatory biomarkers in NSCLC while excluding AIS. Methods: This study included patients who received surgery for lung carcinoma from August 2016 and August 2019. We collected demographic, clinical, laboratory, and outcome information. Inflammatory biomarkers were analyzed using receiver operating characteristic (ROC) curves, Kaplan-Meier survival analysis, and Cox regression to assess their prognostic value. Results: Higher levels of inflammatory biomarkers correlated with poorer survival, with significant differences in overall survival (OS) between high-and low-expression groups. However, multivariate Cox regression identified age, tumor stage, and differentiation as independent prognostic factors, while biomarkers were not independently predictive. Conclusion: Inflammatory biomarkers have short-term prognostic value in invasive NSCLC, but traditional clinical and pathological factors remain key for long-term outcomes.
Keywords: NSCLC, Inflammatory, biomarker, prognostic biomarker, lung cancer
Received: 21 Dec 2024; Accepted: 20 Feb 2025.
Copyright: © 2025 Zhao, Cui, Hu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Hu, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Shuo Chen, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.