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BRIEF RESEARCH REPORT article
Front. Genet.
Sec. Epigenomics and Epigenetics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1548487
This article is part of the Research Topic Genetics and Epigenetics of Host-Pathogen interaction View all articles
Transcriptome Profiling Intrahepatocytic Plasmodium and their Host Hepatocytes based on the Infection Phase and the Zonation of Liver
Provisionally accepted- 1 University Hospital Münster, Münster, Germany
- 2 Youjiang Medical University for Nationalities, Baise, Guangx, China
Intrahepatocytic development is a key stage in the human Plasmodium infection, where sporozoites replicate and transform into merozoites. Due to technological limitations, however, previous gene expression studies of malaria parasite liver infection were mostly conducted in vitro. Our current study compared the gene expression from in vitro-infected parasites at different time points with in vivoinfected parasites and revealed distinct patterns between parasite subpopulations in vitro and in vivo. A joint investigation of the Plasmodium transcriptome and its host transcriptome was made to confer a comprehensive analysis of gene expression in the liver stage of Plasmodium in vivo, which are closer to the disease situation and therefore deepening our understanding of parasite and host transcriptional dynamics during Intrahepatocytic infection.
Keywords: Plasmodium, intraerythrocytic stage, Dual transcriptome, Spatio-temoral analyses, Contrast between in vivo and in vitro
Received: 19 Dec 2024; Accepted: 19 Mar 2025.
Copyright: © 2025 Song and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jian Song, University Hospital Münster, Münster, Germany
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