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TECHNOLOGY AND CODE article
Front. Genet.
Sec. Computational Genomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1532464
weIMPUTE: A User-Friendly Web-Based Genotype Imputation Platform
Provisionally accepted
You Tang 1,2,3
Mingliang Li 1,2
Zhuo Li 1,3,4 Defu Liu 3 Qi Li 1 Xiaodong Hu 3 Jun Yu 2 Jian Lin 1
Chunguang Bi 3 Guanshi Ye 1 Helong Yu 3*- 1 Jilin Agricultural Science and Technology College, Jilin, China
- 2 Jilin Institute of Chemical Technology, Jilin, China
- 3 Jilin Agriculture University, Changchun, Jilin Province, China
- 4 School of Engineering, Guangzhou College of Technology and Business, Guangzhou, Guangdong Province, China
Background: Genotype imputation is a critical preprocessing step in genome-wide association studies (GWAS), enhancing statistical power for detecting associated single nucleotide polymorphisms (SNPs) by increasing marker size.In response to the needs of researchers seeking user-friendly graphical tools for imputation without requiring informatics or computer expertise, we have developed weIMPUTE, a web-based imputation graphical user interface (GUI). Unlike existing genotype imputation software, weIMPUTE supports multiple imputation software, including SHAPEIT, Eagle, Minimac4, Beagle, and IMPUTE2, while encompassing the entire workflow, from quality control to data format conversion. This comprehensive platform enables both novices and experienced users to readily perform imputation tasks. For reference genotype data owners, weIMPUTE can be installed on a server or workstation, facilitating web-based imputation services without data sharing.fields, offering the flexibility to create personalized imputation servers on different operating systems.
Keywords: Imputation, Phasing, GUI, Genotype, Web based
Received: 22 Nov 2024; Accepted: 27 Feb 2025.
Copyright: © 2025 Tang, Li, Li, Liu, Li, Hu, Yu, Lin, Bi, Ye and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Helong Yu, Jilin Agriculture University, Changchun, 130118, Jilin Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.