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ORIGINAL RESEARCH article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1530334
This article is part of the Research Topic Investigating Gene-Related Metabolic and Immunological Therapies in Cancer View all 4 articles
Construction of a risk model associated with tryptophan metabolism and identification of related molecular subtypes in laryngeal squamous cell carcinoma
Provisionally accepted- 1 Department of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Taiyuan, China
- 2 Department of Thyroid and Neck Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
- 3 School of Stomatology, Shanxi Medical University, Taiyuan, Shanxi Province, China
- 4 Department of Head and neck radiotherapy, Shanxi Provincial Cancer Hospital, Taiyuan, Shanxi Province, China
Catabolic metabolites of tryptophan (Trp) are considered to be important microenvironmental factors by suppressing anti-tumor immune responses in cancers. Nevertheless, the effect of Trp metabolism (TM)-related genes (TMRGs) on laryngeal squamous cell carcinoma (LSCC) progression is not yet clear. So, in this study, the TCGA-LSCC, GSE27020, and 40 TMRGs were extracted via public databases to explore the effects of TMRGs on LSCC. Firstly, Weighted Gene Co-expression Network Analysis (WGCNA) was adopted with LSCC samples in TCGA-LSCC to acquire key module, and differentially expressed genes (DEGs) between LSCC and normal samples from TCGA-LSCC were yielded via differential expression analysis. Next, differentially expressed TMRGs (DE-TMRGs) was obtained in key model and DEGs, and prognostic genes were identifde through multiple algorithms. Five prognostic genes, namely SERPINA1, TMC8, RENBP, SDS and FAM107A were finally identified. A risk model was established based on the expressions of prognostic genes
Keywords: tryptophan metabolism, Laryngeal squamous cell carcinoma, BioInformatic, Risk model, immune
Received: 18 Nov 2024; Accepted: 07 Mar 2025.
Copyright: © 2025 Liu, Qin, Luo, Ruan, Lu, Feng and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianfei Yu, Department of Head and neck radiotherapy, Shanxi Provincial Cancer Hospital, Taiyuan, Shanxi Province, China
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