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REVIEW article

Front. Genet.
Sec. RNA
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1524449

Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia

Provisionally accepted
Gui Hong Liu Gui Hong Liu 1A-Rong Jin A-Rong Jin 2*Liang-Liang Sun Liang-Liang Sun 2*Peng Lv Peng Lv 2*Rong Qiao Rong Qiao 2*Wang Lihang Wang Lihang 3
  • 1 Inner Mongolia Medical University, Hohhot, China
  • 2 Inner Mongolia People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China
  • 3 Baotou Medical College, Baotou, China

The final, formatted version of the article will be published soon.

    Objective: Long non-coding RNA (lncRNA) is aberrantly expressed in a variety of tumor diseases. To date, its specific role in acute myeloid leukemia (AML) has not been fully elucidated. This study aims to evaluate the association between aberrant lncRNA expression and poor prognosis in AML patients, and to systematically assess the relationship between aberrant lncRNA expression and AML prognosis. Methods: We conducted a comprehensive literature search in PubMed, Embase, Cochrane Library, CNKI (China National Knowledge Infrastructure), WanFang (China Wanfang Database), VIP (China VIP Database), and Sinomed (China Biomedical Literature Database) to identify relevant Chinese and English articles. The search period covered from the inception of these databases to August 4, 2024. Articles were screened according to predefined inclusion and exclusion criteria, and meta-analysis was performed using Stata. Results: A total of 25 articles were included in the analysis. Aberrant lncRNA expression was significantly associated with reduced overall survival (univariate HR = 2.46, 95%CI 2.11 -2.88, P < 0.001; multivariate HR = 2.46, 95%CI 2.11 -2.88, P < 0.001), event-free survival (HR = 1.51, 95%CI 1.19 -1.90, P = 0.001), recurrence-free survival (HR = 2.82, 95%CI 2.03 -3.91, P < 0.001), and disease-free survival (HR = 2.390, 95%CI 1.037 -5.507, P = 0.041). These findings were statistically significant. The 25 articles collectively identified 22 lncRNAs whose aberrant expression was associated with AML prognosis. Notably, multiple studies highlighted the aberrant expression of lncRNA CRNDE, ZEB2-AS1, and TUG1 as being particularly relevant to AML prognosis. Our meta-analysis revealed that high expression of lncRNA CRNDE and TUG1 was associated with reduced overall survival, while high expression of lncRNA ZEB2-AS1 was linked to decreased disease-free survival, both with statistically significant differences.The expression levels of lncRNAs are closely associated with the prognosis of AML patients and may serve as important indicators for monitoring prognosis in the future. However, further high-quality studies are needed to validate these findings. 【Keywords】: lncRNA; Acute Myeloid Leukemia; Prognosis; Meta-analysis 0 Background Acute myeloid leukemia (AML) is one of the most common malignant diseases in the hematological system, characterized by the malignant proliferation of hematopoietic stem cells.

    Keywords: LncRNA - long noncoding RNA, Acute myeloid leukemia (AML, prognosis, Meta-analysis, review - systematic

    Received: 08 Nov 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Liu, Jin, Sun, Lv, Qiao and Lihang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    A-Rong Jin, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China
    Liang-Liang Sun, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China
    Peng Lv, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China
    Rong Qiao, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.