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ORIGINAL RESEARCH article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1524177
Biological characteristics and prognosis of acute myeloid leukemia in elderly patients
Provisionally accepted- Shaoxing People's Hospital, Shaoxing, China
Background: Our study aimed to investigate the effects of chromosomal aberrations and genetic mutations of elderly individuals diagnosed with AML and determine its prognostic significance.Methods: We retrospectively collected data over nearly 7 years from our hospital, encompassing 90 cases of elderly AML patients. Baseline information of patients was gathered and followed up, and statistical analysis was conducted using SPSS 25.0.Results: Among the 90 elderly non-M3 AML patients, 56 (62.2%) exhibited multiple gene mutations, with 9 (10%) patients displaying five or more gene mutations. The incidence of NPM1 mutation was significantly higher in patients with normal karyotypes compared to those with abnormal karyotypes (P=0.001). Patients with FLT3, ASXL1, or TP53 mutations displayed lower rates of CR compared to wild-type counterparts. Kaplan-Meier analysis revealed that TET2 mutation (P=.0474), FLT3-ITD mutation (P=.0364), TP53 mutation (P=.0031), and 17p abnormality (P=.00285) were predictive of shorter OS. TP53 mutations (P=.0440), 17p abnormalities (P=.0272), 7q abnormalities (P=.0174), and complex karyotypes (P=.0447) were associated with shorter RFS. Conclusion: Our findings suggest that elderly AML patients exhibit distinctive genetic profiles, and favorable prognosis genes do not seem to apply to elderly AML patients.
Keywords: Elderly AML, gene mutation, chromosomal aberrations, prognosis, Retrospective
Received: 07 Nov 2024; Accepted: 21 Mar 2025.
Copyright: © 2025 CHEN and FU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
LEIHUA FU, Shaoxing People's Hospital, Shaoxing, China
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