Shao Xie
1*
Jiahai Ding
2*
Zhao Hao Wang
3
Hengliang Shi
2The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 |
doi: 10.3389/fgene.2025.1518573
GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway
Provisionally accepted- 1 Department of Neurosurgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
- 2 The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
- 3 Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong Province, China
Glioma, a primary intracranial tumor, is characterized by high mortality and disability rates. Exploring the molecular mechanisms underlying the occurrence and development of gliomas and screening targets for gene therapy is of great clinical significance. Golgi phosphoprotein 3 (GOLPH3), predominantly localized at the trans face of Golgi cisternae, has been implicated in the pathogenesis of many cancers. However, its role in the occurrence and development of glioma is still being explored. This study demonstrates that down-regulation of GOLPH3 promotes cell apoptosis and activates the JNK signaling pathway. This is a new report confirming that GOLPH3 regulates the apoptosis of malignant glioma cells through the JNK pathway. Therefore, GOLPH3 emerges as a potentially critical player in glioma development and a viable target for therapeutic intervention.
Keywords: Glioma, GOLPH3, JNK, Apoptosis, Therapeutic target
Received: 28 Oct 2024; Accepted: 07 Jan 2025.
Copyright: © 2025 Xie, Ding, Hao Wang, Shi and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shao Xie, Department of Neurosurgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Jiahai Ding, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Zheng-Quan Yu, Department of Neurosurgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.