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SYSTEMATIC REVIEW article

Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1517513
This article is part of the Research Topic Comparative Genomics and Functional Genomics Analyses in Cancer View all articles

The Relationship of miR-155 Host Gene Polymorphism in the Susceptibility of Cancer: A Systematic Review and Meta-Analysis

Provisionally accepted
Gang Jin Gang Jin 1*Tao Guo Tao Guo 2Jia-Wei Liu Jia-Wei Liu 1Han-Yu Yang Han-Yu Yang 1Jianguo Xu Jianguo Xu 3Yao Pang Yao Pang 1Yi Yang Yi Yang 1Shao-E He Shao-E He 4Kang Yi Kang Yi 5*
  • 1 Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China
  • 2 The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
  • 3 Institute of Evidence-Based Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu Province, China
  • 4 First Hospital of Lanzhou University, Lanzhou, Gansu Province, China
  • 5 Department of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Background: miR-155 is overexpressed in many cancers, highlighting its potential as a biomarker for cancer diagnosis, treatment, and therapeutic evaluation. miR-155 is processed from the miR-155 host gene (MIR155HG). Genetic variations in MIR155HGMIR155HG may influence cancer susceptibility, but existing evidence is inconclusive. This study aimed to evaluate the association of MIR155HGMIR155HG and miR-155 polymorphisms with cancer risk.Material/Methods: A systematic literature search identified 15 case-control studies on three single nucleotide polymorphisms (SNPs): rs767649 (T>A), rs928883 (G>A), and rs1893650 (T>C). Metaanalysis was performed using RevMan 5.4, with odds ratios (ORs) and 95% confidence intervals (CIs) as effect measures.Results: No significant association was observed for rs767649 and rs928883 in overall cancer analysis.However, subgroup analysis revealed rs767649 increased susceptibility to respiratory, digestive, and reproductive cancers, while reducing cancer risk after excluding reproductive cancers (e.g., T vs A, OR=0.84, 95% CI [0.79, 0.90]). rs928883 showed a protective effect for digestive cancers. rs1893650was not significantly associated with cancer risk.Conclusions: MIR155HGMIR155HG and miR-155 polymorphisms influence susceptibility to specific cancer subtypes, particularly respiratory and digestive cancers. These findings underscore the importance of genetic and environmental factors in cancer risk and warrant further investigation.

    Keywords: Cancer, MicroRNA-155, MIR155HG, Single nucleotide polymorphism, Meta-analysis

    Received: 26 Oct 2024; Accepted: 27 Jan 2025.

    Copyright: © 2025 Jin, Guo, Liu, Yang, Xu, Pang, Yang, He and Yi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Gang Jin, Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China
    Kang Yi, Department of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu Province, China

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