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ORIGINAL RESEARCH article

Front. Genet.
Sec. Genetics of Common and Rare Diseases
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1509053

LINC00461 SNPs rs933647 and rs201864123 modify the risk of adenoid hypertrophy susceptibility for children in South China

Provisionally accepted
Chao Hou Chao Hou 1Guang-Hao Li Guang-Hao Li 1Xin Wan Xin Wan 1*Kaining Chen Kaining Chen 1Zhongren Xian Zhongren Xian 2*Xu Kaixiong Xu Kaixiong 3Yingjia Zeng Yingjia Zeng 4*Chenlu Wang Chenlu Wang 1*Wan Yang Wan Yang 1*Zilin Zheng Zilin Zheng 1*Yueling Lin Yueling Lin 1Zhaojin Lu Zhaojin Lu 1*Yanqiu Chen Yanqiu Chen 1*Di Che Di Che 1*Xiaoqiong Gu Xiaoqiong Gu 1*
  • 1 Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
  • 2 Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China
  • 3 the Second Affiliated Hospital, School of Medicine, South China University of Technology, guangzhou, China
  • 4 School of Clinical Medicine, Kunming Medical University, kunming, China

The final, formatted version of the article will be published soon.

    Background: Adenoidal hypertrophy (AH) is commonly observed in childhood and closely linked to obstructive sleep apnea (OSA). Despite the high prevalence of AH, its pathophysiological mechanisms remain incompletely understood. We attempt to explore this issue from a genetic perspective. Elevated levels of LINC00461 have been identified in OSA tissues. We aimed to explore the relationship between susceptibility to adenoid hypertrophy and LINC00461 gene polymorphisms. Methods: We genotyped the LINC00461 single nucleotide polymorphisms (SNPs) rs933647 and rs201864123 in 546 AH patients and 574 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association between the SNPs and AH risk. The SIPI (Susceptible-Infected-Protected-Infected) method was utilized to analyze SNP-SNP interactions between rs933647 and rs201864123. Results: Our study found that the rs933647 GA polymorphism was associated with an increased risk of AH. Similarly, the T allele of SNP rs201864123 increased AH risk in southern Chinese children. Furthermore, SIPI analysis demonstrated an interaction between these SNPs associated with adenoid hypertrophy risk.The LINC00461 rs933647 GA genotype and rs201864123 T variant may contribute to the susceptibility of AH in the child population of China.

    Keywords: Adenoidal hypertrophy, susceptibility, LINC00461, microRNA, SNP

    Received: 10 Oct 2024; Accepted: 05 Feb 2025.

    Copyright: © 2025 Hou, Li, Wan, Chen, Xian, Kaixiong, Zeng, Wang, Yang, Zheng, Lin, Lu, Chen, Che and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xin Wan, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Zhongren Xian, Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China
    Yingjia Zeng, School of Clinical Medicine, Kunming Medical University, kunming, China
    Chenlu Wang, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Wan Yang, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Zilin Zheng, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Zhaojin Lu, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Yanqiu Chen, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Di Che, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Xiaoqiong Gu, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China

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