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ORIGINAL RESEARCH article
Front. Genet.
Sec. Pharmacogenetics and Pharmacogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1509042
Correlation between gene polymorphisms and perioperative analgesia in patients undergoing gynecological surgery
Provisionally accepted- 1 Chongqing Health Center for Women and Children, Chongqing, Chongqing, China
- 2 Women and Children's Hospital of Chongqing Medical University, Chongqing, China
Objectives: This study aims to identify specific single nucleotide polymorphism (SNP) correlated to perioperative analgesia in patients undergoing laparoscopic gynecological surgery.Methods: A total of 200 females meeting specific criteria underwent gynecological laparoscopic procedures under general anesthesia. Preoperative pain sensitivity was evaluated using Pain Sensitivity Questionnaire and Pain Catastrophizing Scale (PCS).Venous blood samples were collected for SNP analysis of nine genes. The study analyzed the correlation between SNPs and pre-operative pain assessment, analgesics usage, and the occurrence of related adverse effects.Results: Six out of nine identified loci showed polymorphisms. The PCS scores were higher in the mutation group (GG+GC) for ADRA2A rs1800544 compared to the CC group (P < 0.05). No differences were observed in visual analog scale or Ramsay sedation scores between the mutation and wild-type groups for any of the SNPs (P < 0.05). Patients in the mutant group (AG+GG) for OPRM1 rs1799971 had higher analgesic usage within 24 hours compared to the wild-type group (P < 0.05). The consumption of intraoperative remifentanil was higher in the mutation group (GG+GC) of ADRA2A rs1800544 than in the CC group. The Multifactorial Dimensionality Reduction analysis suggests that the optimal interaction model includes OPRM1 rs179971 and CYP450 3A4 * 1G rs2242480 together.Patients with GG and AG genotypes of OPRM1 rs1799971 gene required more 24-hour postoperative analgesics after gynecological surgery compared to those with AA genotype. A SNP-SNP interaction was observed between OPRM1 rs179971 and CYP450 3A4 * 1G rs2242480.(www.chictr.org.cn, registration number: ChiCTR2200062425).
Keywords: Postoperative analgesia, Single nucleotide polymorphism, Gynecological laparoscopic operation, pharmacogenomics, personalized medicine
Received: 23 Oct 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Cai, Lei, Gan, Li and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jin Yu, Women and Children's Hospital of Chongqing Medical University, Chongqing, China
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