Comprehensive systematic review and meta-analysis of the TGF-β1 T869C gene polymorphism and autoimmune disease susceptibility

Yawen Zhu ¹ AI QIAN ² Yuan-Yuan Cheng ¹ Ming Li ¹ Chuanbing Huang ^1*

• ¹ rheumatology, Hefei, China
• ² rheumatology Hefei,China, Hefei, China

Objective: Autoimmune diseases result from an aberrant immune response. The association between TGF-β1 gene polymorphisms and risk of developing autoimmune diseases remains to be established. This meta-analysis aimed to reassess the relationship between TGF-β1 T869C gene polymorphisms and susceptibility to autoimmune diseases.We conducted a comprehensive search of seven electronic databases for case-control studies investigating the TGF-β1 T869C polymorphism in relation to autoimmune diseases, Including rheumatoid arthritis, systemic lupus erythematosus and other five diseases. The search encompassed publications published up to June 2024. Studies were categorized by ethnicity into three groups: Asian, Caucasian, and mixed-ethnicity groups. Five different genetic models were assessed, and the quality of the included studies was evaluated using the Newcastle-Ottawa Scale (NOS). Statistical analyses were performed using Stata 14.0, by calculating the odds ratio (OR) and 95% confidence interval (CI).Results:A total of 32 case-control studies (31 articles), comprising 4,304 cases and 4,664 controls, were included in this meta-analysis. The overall analysis indicated no significant association between TGF-β1 T869C gene polymorphism and susceptibility to autoimmune diseases.Ethnic subgroup analysis showed that the TGF-β1 T869C allele model (T vs. C: OR = 1.422, 95% CI = 1.109-1.824, P = 0.006), homozygous model (TT vs. CC: OR = 1.923, 95% CI = 1.232-3.004, P = 0.004), and dominant model (TT + TC vs. CC: OR = 1.599, 95% CI = 1.164-2.196, P = 0.004) were associated with autoimmune disease susceptibility in Asians. In the disease subgroup analysis, the results showed that the TGF-β1 T869C allele model (T vs. C: OR = 1.468, 95% CI = 1.210-1.781, P = 0.000), recessive model (TT vs. TC + CC: OR = 1.418, 95% CI = 1.097-1.832, P = 0.008), dominant model (TT + TC vs. CC: OR = 1.747, 95% CI = 1.330-2.295, P = 0.000), homozygous model (TT vs. CC: OR = 1.937, 95% CI = 1.373-2.734, P = 0.000)were associated with rheumatoid arthritis susceptibility.BThe findings of this meta-analysis suggest that carrying the T allele of the TGF-β1 T869C polymorphism increases the risk of autoimmune diseases in Asian populations. Moreover, individuals carrying the T allele are at higher risk of developing rheumatoid arthritis.