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ORIGINAL RESEARCH article
Front. Genet.
Sec. Livestock Genomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1461385
This article is part of the Research Topic Advances in Livestock Genetics: Enhancing Breeding Practices and Improving Animal Health View all 6 articles
Genetic determinism of cortisol levels in pig
Provisionally accepted
Elena E Terenina 1*
Nathalie Iannuccelli 1 Yvon Billon 2
Katia Feve 1 Laure Gress 1
Darya Bazovkina 3 Pierre Mormede 1
Catherine Larzul 1- 1 INRAE Occitanie Toulouse, Castanet-Tolosan, France
- 2 INRAE Nouvelle Aquitaine Poitiers, Lusignan, France
- 3 Institute of Cytology and Genetics, Russian Academy of Sciences (RAS), Novosibirsk, Novosibirsk Oblast, Russia
In facing the challenge of sustainability, animal breeding provides the option to improve animal robustness. In the search for new selection criteria related to robustness, the hypothalamic-pituitaryadrenocortical (HPA) axis is studied as a major neuroendocrine system involved in metabolic regulations and adaptive responses. Indeed, HPA axis activity is strongly influenced by genetic factors acting at several levels of the axis. The adrenocorticotropic hormone (ACTH) stimulation test has long been used to analyze interindividual and genetic differences in HPA axis activity in several species, including pigs. To uncover the genetic determinism of HPA activity and its influence on functional traits and robustness, a divergent selection experiment was carried out for three
Keywords: pig, HPA axis, Glucocorticoid receptor, CBG, Adrenocorticotropic Hormone, robustness
Received: 08 Jul 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Terenina, Iannuccelli, Billon, Feve, Gress, Bazovkina, Mormede and Larzul. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Elena E Terenina, INRAE Occitanie Toulouse, Castanet-Tolosan, 75338, France
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