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ORIGINAL RESEARCH article
Front. Genet.
Sec. Statistical Genetics and Methodology
Volume 16 - 2025 |
doi: 10.3389/fgene.2025.1390605
This article is part of the Research Topic Molecular Mechanisms and Therapeutic Biomarkers in Inflammatory Diseases View all 4 articles
Role of PD-L1 in mediating the effect of lipid on Ulcerative colitis: A Mediation Mendelian Randomization Study
Provisionally accepted- 1 Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- 2 Shanghai Changning Tianshan Traditional Chinese Medicine Hospital, Shanghai, China
Recent evidence suggests that lipids play a crucial role in intestinal metabolic balance and are closely linked to ulcerative colitis (UC). However, the mechanisms underlying their effects remain unclear. This study employed Mendelian randomization (MR) to investigate the relationships among lipids, inflammatory factors, and UC. We analyzed data on 179 lipids from the GeneRISK cohort (7,174 individuals), 91 inflammation-related proteins from the EBI GWAS Catalog (14,824 participants), and UC GWAS summary statistics from the FinnGen Biobank (411,317 samples). Associations were assessed using inverse variance weighted (IVW) and Bayesian-weighted MR (BWMR) methods. A mediation analysis was conducted to explore the potential role of inflammatory factors in mediating lipid effects on UC. MR analysis revealed a significant negative association between sterol ester (27:1/20:4) levels and UC
Keywords: ulcerative colitis, Lipids, Inflammatory factors, Mendelian randomization, Mediation analysis
Received: 04 Mar 2024; Accepted: 31 Jan 2025.
Copyright: © 2025 Li, Wang, Hu and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Boyun Sun, Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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