Skip to main content

ORIGINAL RESEARCH article

Front. Genet.
Sec. Statistical Genetics and Methodology
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1366743
This article is part of the Research Topic Mendelian Randomization: the Study of Causal Relationships between Tumors and Underlying Pathogenic Factors View all 15 articles

Causal effects of metabolites on malignant neoplasm of bone and articular cartilage: a Mendelian randomization study

Provisionally accepted
Du Yongwei Du Yongwei 1,2*Xiao xiqiu Xiao xiqiu 3,4liu fuping liu fuping 5Zhu wenqing Zhu wenqing 2Mo jianwen Mo jianwen 2Zhen Liu Zhen Liu 6*
  • 1 First Affiliated Hospital of Gannan Medical University, Ganzhou, China
  • 2 Department of Orthopedic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
  • 3 The First People's Hospital of Nankang District, Ganzhou, Jiangxi Province, China
  • 4 Department of Orthopedics, Ganzhou Municipal Hospital, Ganzhou, China
  • 5 Department of Emergency, Shangyou County People's Hospital, Ganzhou, China
  • 6 Department of Rehabilitation Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China

The final, formatted version of the article will be published soon.

    Objective: Previous research has demonstrated that metabolites play a significant role in modulating disease phenotypes; nevertheless, the causal association between metabolites and malignant malignancies of bones and joint cartilage (MNBAC)has not been fully elucidated.Methods: This study used two-sample Mendelian randomization (MR) to explore the causal correlation between 1400 metabolites and MNBAC. Data from recent genomewide association studies (GWAS) involving 8,299 individuals were summarized. The GWAS summary data for metabolites were acquired from the IEU Open GWAS database, while those for MNBAC were contributed by the Finnish Consortium. We employed eight distinct MR methodologies: simple mode, maximum likelihood estimator, MR robust adjusted profile score, MR-Egger, weighted mode, weighted median, MR-PRESSO and inverse variance weighted to scrutinize the causal association between metabolites engendered by each gene and MNBAC. Consequently, we evaluated outliers, horizontal pleiotropy, heterogeneity, the impact of single nucleotide polymorphisms (SNPs), and adherence to the normal distribution assumption in the MR analysis.

    Keywords: Mendelian randomization, causality, Metabolites, neoplasm, Bone, Articular, Cartilage

    Received: 07 Jan 2024; Accepted: 07 Feb 2025.

    Copyright: © 2025 Yongwei, xiqiu, fuping, wenqing, jianwen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Du Yongwei, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
    Zhen Liu, Department of Rehabilitation Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.