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ORIGINAL RESEARCH article

Front. Genet.
Sec. RNA
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1504114

Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System XC-/GPX4 pathway

Provisionally accepted
Jiejie Hu Jiejie Hu 1,2,3Lijun Qin Lijun Qin 4*Guoqiang Zhu Guoqiang Zhu 5*Jingjing Ren Jingjing Ren 6*Hongxia Wang Hongxia Wang 7*Jing Jin Jing Jin 1*Haixue Zheng Haixue Zheng 6Dan Li Dan Li 6*Chaoming Ge Chaoming Ge 1*
  • 1 Department of Neurology, Lanzhou University Second Hospital, Lanzhou, China
  • 2 Lanzhou University, Lanzhou, Gansu Province, China
  • 3 Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
  • 4 Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
  • 5 School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou, China
  • 6 State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute (CAAS), Lanzhou, Gansu Province, China
  • 7 Gansu University of Traditional Chinese Medicine, Lanzhou, China

The final, formatted version of the article will be published soon.

    Introduction: Cerebral ischemia-reperfusion (IR) causes severe secondary brain injuryinjury to the brain. Previously studies have demonstrated thatshown ferroptosis is involved in IR-induced brain IR injury. However, whether IR induces ferroptosis in brain microvascular endothelial cells (BMVECs) is not fully understood. Materials and methods: Oxygen-glucose deprivation/reoxygenation (OGDR) was performed in bEND.3 cells to mimic IR injury through in vitro expriments, and a focal cerebral IR model waswere created in C57BL/6 mice. Transcriptomic sequencing of the cells wais performed first, followed by bioinformatics analysis. The differently expressed genes (DEGs) enrichment analysis highlighted the ferroptosis-related pathways. Results:

    Keywords: ferroptosis, ischemia/reperfusion, BMVECs, SESN2, System xc-, RNA-Seq, Hub gene UsingThrough Venn analysis, nine9 ferroptosis-related DEGs were identifiedscreened out:

    Received: 30 Sep 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Hu, Qin, Zhu, Ren, Wang, Jin, Zheng, Li and Ge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lijun Qin, Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
    Guoqiang Zhu, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou, China
    Jingjing Ren, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute (CAAS), Lanzhou, 730046, Gansu Province, China
    Hongxia Wang, Gansu University of Traditional Chinese Medicine, Lanzhou, China
    Jing Jin, Department of Neurology, Lanzhou University Second Hospital, Lanzhou, China
    Dan Li, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute (CAAS), Lanzhou, 730046, Gansu Province, China
    Chaoming Ge, Department of Neurology, Lanzhou University Second Hospital, Lanzhou, China

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