Skip to main content

CASE REPORT article

Front. Genet.
Sec. Genetics of Common and Rare Diseases
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1491870

Treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil: A Case Report

Provisionally accepted
Mingyue ZHUANG Mingyue ZHUANG 1Yonglong Xu Yonglong Xu 1Shiyi Zhong Shiyi Zhong 1Ziyuan Tian Ziyuan Tian 1Qingwu Liu Qingwu Liu 2Ding Quan Yang Ding Quan Yang 2*
  • 1 Beijing University of Chinese Medicine, Beijing, China
  • 2 China-Japan Friendship Hospital, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Hypotrichosis simplex of the scalp (HSS) is a clinically rare monogenic autosomal dominant disorder associated with variants in the gene CDSN, which encodes the desmosome protein corneodesmosin. Although studies have reported that some medications can improve the symptoms of hair loss in HSS, there is still a lack of definitive and effective treatments for this disease.We report a familial case of HSS in an 8-year-old male child diagnosed with HSS caused by a mutation in CDSN, who was treated with botanical extracts in combination with minoxidil, which resulted in significant hair growth after two treatments. This is the first study describing the improvement of clinical symptoms of HSS with oral botanical extracts. This suggests that botanical extracts in combination with minoxidil may be a therapeutic approach for HSS in the clinic.

    Keywords: Botanical extracts, Hypotrichosis simplex of the scalp, Hair disease, Family genealogy, genetic mutation

    Received: 05 Sep 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 ZHUANG, Xu, Zhong, Tian, Liu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ding Quan Yang, China-Japan Friendship Hospital, Beijing, 100029, Beijing Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.