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ORIGINAL RESEARCH article

Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1475511
This article is part of the Research Topic Investigating Gene-Related Metabolic and Immunological Therapies in Cancer View all articles

Holliday Junction Recognition Protein (HJURP) could reflect the clinical outcomes of lung adenocarcinoma patients, and impact the choice of precision therapy

Provisionally accepted
Xixi Gao Xixi Gao Yingqing Zhang Yingqing Zhang Ming Zhang Ming Zhang Yuejiao Sun Yuejiao Sun *
  • First Hospital of Jiaxing, Jiaxing, China

The final, formatted version of the article will be published soon.

    Lung adenocarcinoma (LUAD) is the most prevalent subtype of non-small cell lung cancer (NSCLC), characterized by poor prognosis and a high mortality rate. Identifying reliable prognostic biomarkers and potential therapeutic targets is crucial for improving patient outcomes.We conducted a comprehensive analysis of HJURP expression in LUAD using data from four cohorts: TCGA-LUAD (n=453), GSE31210 (n=226), GSE68465 (n=442), and GSE72094 (n=386). Univariate Cox regression analysis was employed to identify prognostic genes, with Kaplan-Meier survival analysis used to assess the predictive power of HJURP. Functional enrichment analyses were performed using MetaScape and FGSEA, and spatial transcriptomics and single-cell sequencing data were analyzed to explore HJURP's distribution and potential functions. Additionally, correlations between HJURP expression and genetic alterations, immune cell infiltration, and potential therapeutic responses were evaluated.HJURP was identified as a significant prognostic biomarker in all four cohorts, with high expression associated with increased risk of overall survival (OS) death (TCGA-LUAD:

    Keywords: HJURP, Lung Adenocarcinoma, prognosis, Immune infiltration, genetic alterations

    Received: 04 Aug 2024; Accepted: 05 Nov 2024.

    Copyright: © 2024 Gao, Zhang, Zhang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuejiao Sun, First Hospital of Jiaxing, Jiaxing, China

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