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ORIGINAL RESEARCH article

Front. Genet.
Sec. Human and Medical Genomics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1470310
This article is part of the Research Topic Genetic Research on Common Orthopedic Diseases View all articles

MicroRNA Binding Site Variants -New Potential Markers of Primary Osteoporosis in Men and Women

Provisionally accepted
Bulat Yalaev Bulat Yalaev 1Roman Deev Roman Deev 1Anton Tyurin Anton Tyurin 2*Ramil Salakhov Ramil Salakhov 1Kirill Smirnov Kirill Smirnov 1Anna Eremkina Anna Eremkina 1Natalia Mokrysheva Natalia Mokrysheva 1Ildar Minniakhmetov Ildar Minniakhmetov 1Rita Khusainova Rita Khusainova 1,2
  • 1 Endocrinology Research Center, Moscow, Moscow Oblast, Russia
  • 2 Bashkir State Medical University, Ufa, Russia

The final, formatted version of the article will be published soon.

    The identification of significant DNA markers of primary osteoporosis may gain new insights by studying genome regions involved in mechanisms of epigenetic regulation through interactions with microRNAs. The authors searched for associations of polymorphic variants of microRNA binding sites of mRNA target genes and polymorphic loci of microRNA genes with primary osteoporosis in a cohort of women and men from the Volga-Ural region of Russia (N=1.177). Using case-control association analysis, the authors found that rs1061947 (COL1A1), rs10793442 (ZNF239), rs6854081 (FGF2), and rs11614913 (miR-196a) were associated with osteoporotic fractures; rs5854 (MMP1) and rs2910164 (miR-146a) were associated with low bone mineral density; and rs10098470 (TPD52), rs11540149 (VDR), rs1042673 (SOX9), rs1054204 (SPARC), and rs1712 (FBXO5) were markers of both fractures and low bone mineral density. Among the identified associations, ethno specific trends were found, as well as sex-specific associations. Prognostic models were developed, among which the model for predicting osteoporosis in general in women (AUC=0.909) achieved the highest level of predictive value. Thus, the potential role of polymorphic variants of microRNA binding sites in the development of primary osteoporosis in men and women from the Volga-Ural region of Russia was demonstrated.

    Keywords: Osteoporosis, fractures, microRNA binding sites, Femoral neck, Spine, Radial bone

    Received: 25 Jul 2024; Accepted: 20 Sep 2024.

    Copyright: © 2024 Yalaev, Deev, Tyurin, Salakhov, Smirnov, Eremkina, Mokrysheva, Minniakhmetov and Khusainova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Anton Tyurin, Bashkir State Medical University, Ufa, Russia

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