Jian Liu ¹ Xinzheng Xue ¹ Pengbo Wen ² Qian Song ^3* Jun Yao ^3* Shuguang Ge ^2*

• ¹ School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China
• ² School of Medicine Information and Engineering , Xuzhou Medical University, Xuzhou, Jiangsu Province, China
• ³ Taizhou Cancer Hospital, Taizhou, Zhejiang Province, China

The combination of next-generation sequencing technology and Cancer Genome Atlas (TCGA) data provides unprecedented opportunities for the discovery of cancer subtypes. Through comprehensive analysis and in-depth analysis of the genomic data of a large number of cancer patients, researchers can more accurately identify different cancer subtypes and reveal their molecular heterogeneity. In this paper, we propose the SMMSN (Self-supervised Multi-fusion Strategy Network) model for the discovery of cancer subtypes. SMMSN can not only fuse multi-level data representations of single omics data by Graph Convolutional Network (GCN) and Stacked Autoencoder Network (SAE), but also achieve the organic fusion of multi--omics data through multiple fusion strategies. In response to the problem of lack label information in multi-omics data, SMMSN propose to use dual self-supervise method to cluster cancer subtypes from the integrated data. We conducted experiments on three labeled and five unlabeled multi-omics datasets to distinguish potential cancer subtypes. Kaplan-Meier survival curves showed that SMMSN can obtain cancer subtypes with significant differences. In the case analysis of Glioblastoma Multiforme (GBM) and Breast Invasive Carcinoma (BIC), we conducted survival time and age distribution analysis, drug response analysis, differential expression analysis, functional enrichment analysis on the predicted cancer subtypes. The research results showed that SMMSN can discover clinically meaningful cancer subtypes.