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MINI REVIEW article

Front. Genet.
Sec. RNA
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1460902
This article is part of the Research Topic Role of RNA post-transcriptional modification (PTM) mutations in diseases View all articles

Variation of tRNA modifications with and without intron dependency

Provisionally accepted
Sachiko Hayashi Sachiko Hayashi *
  • Graduate School of Science, University of Hyogo, Ako-gun, Japan

The final, formatted version of the article will be published soon.

    tRNAs have recently gained attention for their novel regulatory roles in translation and for their diverse functions beyond translation. One of the most remarkable aspects of tRNA biogenesis is the incorporation of various chemical modifications, ranging from simple base or ribose methylation to more complex hypermodifications such as formation of queuosine and wybutosine. Some tRNAs are transcribed as intron-containing pre-tRNAs. While the majority of these modifications occur independently of introns, some are catalyzed in an intron-inhibitory manner, and in certain cases, they occur in an intron-dependent manner. This review focuses on pre-tRNA modification, including intron-containing pre-tRNA, in both intron-inhibitory and intron-dependent fashions. Any perturbations in the modification and processing of tRNAs may lead to a range of diseases and disorders, highlighting the importance of understanding these mechanisms in molecular biology and medicine.

    Keywords: RNA modification, tRNA, intron, pre-tRNA, processing, enzyme

    Received: 07 Jul 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Hayashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sachiko Hayashi, Graduate School of Science, University of Hyogo, Ako-gun, Japan

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