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ORIGINAL RESEARCH article
Front. Genet.
Sec. Livestock Genomics
Volume 15 - 2024 |
doi: 10.3389/fgene.2024.1457634
The Genetic Characterization of Germplasm and Identification of the Litter Size Trait Associated Candidate Genes in Dexin Mutton & Fine-Wool Sheep
Provisionally accepted
Mengting Zhu
1*
Pengfei Li
1*
Weiwei Wu
2*
Wenxin Zheng
2*
Juncheng Huang
2*
Hanikzi Tulafu
2*
Changchun Lin
2*
Weikun Tao
2*
Qi Aladaer
1*- 1 Xinjiang Agricultural University, Ürümqi, China
- 2 Institute of Animal Science, Xinjiang Academy of Animal Science, Urumqi, Xinjiang, China
Xinjiang is a major province of sheep breeding in China, which plays an important role in meeting people's needs for meat products, increasing farmers' income and sustainable development of animal husbandry. However, the genetic differentiation relationship between breeds was not clear, and most sheep had low fecundity, which seriously restricted the efficient development of sheep industry. Therefore, this study used the whole genome resequencing to detect the genetic variation of Dexin mutton & fine-wool sheep, explored the selected regions and important genes of the litter size traits, analyzed the genetic mechanism of reproductive traits, and provided new insights for the high fecundity breeding of sheep. A total of 5,236.338 G genome data and 35,884,037 SNPs were obtained. Furthermore, we identified 39 selection signals spanning candidate genes, 99 genes were significantly associated related to growth, reproduction and immunity, among which, BRIP1, BMPR1B, BMP4, NGF etc. genes, and MAKP signaling pathway, Fanconi anemia pathway and Thyroid hormone signaling pathway and other signaling pathways were significantly correlated with litter size trait. Among them, we identified NGF, TrKA and BRIP1 genes was the important genes for sheep litter size traits and the mutation frequencies of 9 SNPs in BRIP1 gene were significantly different in domestic sheep in the world. The research provided new insights for the breeding of self-cultivated meat fine-wool sheep.
Keywords: Dexin mutton & fine-wool sheep, Litter size trait, selection signature, candidate genes, Whole-genome resequencing
Received: 01 Jul 2024; Accepted: 31 Jul 2024.
Copyright: © 2024 Zhu, Li, Wu, Zheng, Huang, Tulafu, Lin, Tao and Aladaer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mengting Zhu, Xinjiang Agricultural University, Ürümqi, China
Pengfei Li, Xinjiang Agricultural University, Ürümqi, China
Weiwei Wu, Institute of Animal Science, Xinjiang Academy of Animal Science, Urumqi, Xinjiang, China
Wenxin Zheng, Institute of Animal Science, Xinjiang Academy of Animal Science, Urumqi, Xinjiang, China
Juncheng Huang, Institute of Animal Science, Xinjiang Academy of Animal Science, Urumqi, Xinjiang, China
Hanikzi Tulafu, Institute of Animal Science, Xinjiang Academy of Animal Science, Urumqi, Xinjiang, China
Changchun Lin, Institute of Animal Science, Xinjiang Academy of Animal Science, Urumqi, Xinjiang, China
Weikun Tao, Institute of Animal Science, Xinjiang Academy of Animal Science, Urumqi, Xinjiang, China
Qi Aladaer, Xinjiang Agricultural University, Ürümqi, China
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