Hongjie You
Hui Zhang
*
Xiaofeng Jin
*The final, formatted version of the article will be published soon.
REVIEW article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 15 - 2024 |
doi: 10.3389/fgene.2024.1453191
Dysregulation of Ubiquitination modification in Renal Cell Carcinoma
Provisionally accepted- Ningbo First Hospital, Ningbo, Zhejiang Province, China
Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and dysregulation, is associated with the occurrence and development of RCC. This review focuses on several abnormal signaling pathways caused by E3 ligases and deubiquitinases. Additionally, we discuss research progress in RCC treatment by targeting key enzymes related to ubiquitination modifications.
Keywords: E3 ubiquitin ligases, Renal cell carcinoma (RCC), Ubiquitination, deubiquitination, protac (proteolysis targeting chimera)
Received: 22 Jun 2024; Accepted: 26 Nov 2024.
Copyright: © 2024 You, Zhang, Jin and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hui Zhang, Ningbo First Hospital, Ningbo, 315016, Zhejiang Province, China
Xiaofeng Jin, Ningbo First Hospital, Ningbo, 315016, Zhejiang Province, China
Zejun Yan, Ningbo First Hospital, Ningbo, 315016, Zhejiang Province, China
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