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ORIGINAL RESEARCH article

Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1449491

Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer

Provisionally accepted
feifei yao feifei yao 1*feng guo feng guo 1chuanzhong sun chuanzhong sun 1erdong wang erdong wang 2hang wang hang wang 1na li na li 1
  • 1 Suzhou Hospital of Anhui Medical University, Suzhou, China
  • 2 Yiwu Chouzhou Hospital, Yiwu, China

The final, formatted version of the article will be published soon.

    Objectives: This study employs bibliometric analysis to track evolution and identify trends of key topics in ferroptosis within the context of lung cancer. By identifying emerging research areas, our aim is to provide valuable insights and directions for researchers in this field. Methods: Relevant papers and reviews on ferroptosis in lung cancer were retrieved from the Web of Science Core Collection database on February 5, 2024. Bibliometric analysis was conducted using CiteSpace 6.2.R3, VOSviewer 1.6.20, R 4.3.0, Bibliometric and Microsoft Excel 2019. Results: From 2015 to 2020, publications related to ferroptosis in lung cancer were sparse but showed a steady increase. Post-2020, there has been a significant surge, with a 6.4-fold increase observed by 2023. Overall, authors from 4033 institutions across 42 countries/regions contributed 606 papers published in 262 academic journals. China emerged as the leading contributor, while the United States maintained dominance. Lifang Ma was the most prolific author, with DIXON SJ, YANG WS, and STOCKWELL BR being the most frequently co-cited. Effective communication and collaboration among scholars are lacking. Key journals include Frontiers in Pharmacology for publication output, and Nature and Cell for citation frequency. Research focuses on molecular mechanisms of ferroptosis, including endoplasmic reticulum stress, tumor microenvironment, and autophagy. Therapeutic targets like GPX4, SLC7A11, P53, FSP1, Nrf2, LSH, STYK1/NOK, and ACSL4 are prominent. Traditional Chinese medicine also shows clinical value in ferroptosis research. Conclusion: Ferroptosis, as a promising research avenue with significant clinical applications in lung cancer, continues to undergo rapid development. The study of iron death in lung cancer will remain a critical research focus in the future.

    Keywords: ferroptosis, lung cancer, Citespace, bibliometric analysis, Knowledge mapping

    Received: 15 Jun 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 yao, guo, sun, wang, wang and li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: feifei yao, Suzhou Hospital of Anhui Medical University, Suzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.