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ORIGINAL RESEARCH article

Front. Genet.
Sec. Immunogenetics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1442938

Combined maternal KIR2DL4 and fetal HLA-G polymorphisms were associated with preeclampsia in a Han Chinese population

Provisionally accepted
Yantuanjin Ma Yantuanjin Ma 1*Yuan Qian Yuan Qian 2Hong Jiang Hong Jiang 3Haiyun Meng Haiyun Meng 4Yang Wang Yang Wang 4Yuling Yang Yuling Yang 3
  • 1 Institute of Biomedical Engineering, Kunming Medical University, Kunming, China
  • 2 Kunming Maternal and Child Health Hospital, Kunming, Yunnan Province, China
  • 3 College of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan Province, China
  • 4 Obstetrics Department, Yan'an Hospital Affiliated To Kunming Medical University, Kunming, Yunnan Province, China

The final, formatted version of the article will be published soon.

    Preeclampsia is the main cause of maternal and infant mortality and morbidity during pregnancy. Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) and human leukocyte antigen G (HLA-G) play crucial roles in immune tolerance at the maternalfetal interface. In this case-control study, 154 maternal-fetal pairs were recruited, including 74 pairs with preeclampsia (56 of 74 pairs from family triads) and 80 pairs with a normal pregnancy (78 of 80 pairs from family triads). SNaPshot technology was used to detect genetic polymorphisms for 7 TagSNPs in the KIR2DL4 and HLA-G genes. Among the fetal HLA-G gene polymorphisms, rs9380142 (A vs. G: OR=2.802, 95% CI=1.761-4.458) and rs1063320 (G vs. C: OR= 1.807, 95% CI=1.144-2.852) differed between the preeclampsia group and the control group. The transmission disequilibrium test (TDT) suggested that the differences in the rs9380142 G/A polymorphism in foetuses between preeclampsia triads and control triads were due to differences in transmission from the parents (P = 0.001). There was no significant difference in the distribution of maternal KIR2DL4 alleles or genotype frequency between the preeclampsia group and the control group. Gene-gene interaction analysis revealed that the combined genotypes of maternal rs649216-CC and fetal rs9380142-GG, maternal rs1051456-CG/GG and fetal rs9380142-GG, maternal rs34785252-CC and fetal rs9380142-AA/GA, and maternal rs34785252-CC/AA and fetal rs9380142-GG were associated with a significantly lower risk of preeclampsia. Therefore, this study suggested that the combination of maternal KIR2DL4 and fetal HLA-G polymorphisms was associated with preeclampsia in a Han Chinese population.

    Keywords: Preeclampsia, polymorphism, Placenta, HLA-G, KIR2DL4

    Received: 04 Jun 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Ma, Qian, Jiang, Meng, Wang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yantuanjin Ma, Institute of Biomedical Engineering, Kunming Medical University, Kunming, China

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