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REVIEW article

Front. Genet.
Sec. Human and Medical Genomics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1440430
This article is part of the Research Topic Gene delivery strategies for disease treatment View all 4 articles

Management of triple-negative breast cancer by natural compounds through different mechanistic pathways

Provisionally accepted
Mohammed Kaleem Mohammed Kaleem 1Mandar Thool Mandar Thool 2Nitin G. Dumore Nitin G. Dumore 1Abdulrasheed O. Abdulrahman Abdulrasheed O. Abdulrahman 3Wasim Ahmad Wasim Ahmad 4Amal Almostadi Amal Almostadi 3Mohammad H. Alhashmi Mohammad H. Alhashmi 3Mohammad A. Kamal Mohammad A. Kamal 5SHAMS TABREZ SHAMS TABREZ 3,6*
  • 1 Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
  • 2 Babasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India
  • 3 King Abdulaziz University, Jeddah, Saudi Arabia
  • 4 National Institute of Unani Medicine (NIUM), Bangalore, Karnataka, India
  • 5 Sichuan University, Chengdu, China
  • 6 King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Makkah, Saudi Arabia

The final, formatted version of the article will be published soon.

    Triple-negative breast cancer (TNBC) is the most severe form of breast cancer, characterized by the loss of estrogen, progesterone, and human epidermal growth factor receptors. It is considered to be caused by various genetic and epigenetic factors, resulting in poor prognosis. Epigenetic changes, such as DNA methylation and histone modification, are the leading mechanisms responsible for TNBC progression and metastasis. This review comprehensively covers the various subtypes of TNBC and their epigenetic causes. In addition, the genetic association of TNBC with all significant genes and signaling pathways linked to the progression of this form of cancer has been enlisted. Furthermore, the possible uses of natural compounds through different mechanistic pathways have also been discussed in detail for the successful management of TNBC.

    Keywords: DNA Methylation, Genes, histone modification, natural drugs, TNBC, epigenetic mechanims

    Received: 29 May 2024; Accepted: 09 Jul 2024.

    Copyright: © 2024 Kaleem, Thool, Dumore, Abdulrahman, Ahmad, Almostadi, Alhashmi, Kamal and TABREZ. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: SHAMS TABREZ, King Abdulaziz University, Jeddah, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.