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ORIGINAL RESEARCH article

Front. Genet.
Sec. Statistical Genetics and Methodology
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1436512

Mendelian Randomization Analysis Reveals Genetic Evidence for a Causal Link Between Inflammatory Bowel Disease and Uterine Cervical Neoplasms

Provisionally accepted
Chunge Cao Chunge Cao 1*Hu Zhao Hu Zhao 1Xiaohu Chen Xiaohu Chen 2Liqiang Zhu Liqiang Zhu 1Dajun Cai Dajun Cai 1Chaoyan Yue Chaoyan Yue 2
  • 1 Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China
  • 2 Obstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Background: Inflammatory bowel disease (IBD) has been reported to be associated with risk of uterine cervical neoplasm. We aimed to evaluate the causal relationship between IBD and uterine cervical neoplasm using a bidirectional Mendelian randomization analysis. Methods:We derived instrumental variables for IBD, including Crohn's disease and ulcerative colitis, from the IEU Open genome-wide association study (GWAS) database, and for the histological subtypes of uterine cervical neoplasm from the FinnGen repository's GWAS data. The collected GWAS data predominantly represent individuals of European ancestry. The inverse-variance weighted (IVW) method was employed as primary analysis approach. Results: IBD (IVW odds ratio = 1.127, 95% confidence interval = 1.016-1.251; p = 0.024) and CD (IVW odds ratio = 1.119, 95% confidence interval = 1.023-1.224; p = 0.014) exhibited a significant causal effect on malignant cervical carcinoma. Sensitivity analyses confirmed these findings. Conclusions:Genetically predicted IBD and CD are risk factors for the development of malignant cervical carcinoma. Patients with IBD and CD require specific attention to prevent cervical squamous cell carcinoma. Further studies to elucidate the underlying mechanisms may reveal new therapeutic targets.

    Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, Uterine cervical neoplasm, Mendelian randomization

    Received: 22 May 2024; Accepted: 11 Dec 2024.

    Copyright: © 2024 Cao, Zhao, Chen, Zhu, Cai and Yue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chunge Cao, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China

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