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ORIGINAL RESEARCH article

Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1435132

Exploring the Therapeutic Potency of Cryptotanshinone in Cervical Cancer: A Multi-omics and Network Pharmacology Approach

Provisionally accepted
Zenghong Lu Zenghong Lu 1*Gangfeng Zhu Gangfeng Zhu 2Xiaofei Feng Xiaofei Feng 1*Yi Xiang Yi Xiang 1,3Cixiang Chen Cixiang Chen 2*Huiting Yuan Huiting Yuan 2Zhixing Chen Zhixing Chen 4*
  • 1 Department of Oncology, The First Affiliated Hospital, Gannan Medical University, Ganzhou, Jiangxi Province, China
  • 2 The First Clinical Medical College, Gannan Medical University,, Ganzhou, Jiangxi Province, China
  • 3 Department of Radiology, Zhongda Hospital, Southeast University, Nanjing, Liaoning Province, China
  • 4 Department of Gastroenterology, The First Affiliated Hospital, Gannan Medical University, Ganzhou, China

The final, formatted version of the article will be published soon.

    Introduction: Cervical cancer remains a significant challenge in oncology with an escalating demand for novel therapeutic strategies that can navigate the complexities of its pathophysiology. This study elucidated the antineoplastic effects of cryptotanshinone, a derivative of danshen (Salvia miltiorrhiza), a herb widely utilized in traditional Chinese medicine practices. Methods: Employing a comprehensive multi-omics approach, including transcriptomic, proteomic, and bioinformatics analyses, we investigated the potential effects of cryptotanshinone on cervical cancer through data mining and computational analysis. Results and Discussion: Our results demonstrated that the potential of cryptotanshinone to disrupted cancer cell proliferation and induced apoptosis may be ascribed to its modulation of gene expression and interaction with specific protein networks. Furthermore, network pharmacology and pathway enrichment analyses identified critical hubs and signaling pathways, suggesting a multi-targeted mechanism of action. Furthermore, the establishment of a prognostic model, which is founded upon differentially expressed genes linked to cryptotanshinone treatment, underscores its promising role as both a prognostic biomarker and a therapeutic agent. These insights pave the way for the integration of cryptotanshinone into therapeutic regimens, offering a promising avenue for enhancing the efficacy of cervical cancer treatment and patient outcomes.

    Keywords: Cryptotanshinone, cervical cancer, Multi-omics analysis, Network Pharmacology, bioinformatics, Prognostic biomarkers

    Received: 19 May 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Lu, Zhu, Feng, Xiang, Chen, Yuan and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zenghong Lu, Department of Oncology, The First Affiliated Hospital, Gannan Medical University, Ganzhou, Jiangxi Province, China
    Xiaofei Feng, Department of Oncology, The First Affiliated Hospital, Gannan Medical University, Ganzhou, Jiangxi Province, China
    Cixiang Chen, The First Clinical Medical College, Gannan Medical University,, Ganzhou, Jiangxi Province, China
    Zhixing Chen, Department of Gastroenterology, The First Affiliated Hospital, Gannan Medical University, Ganzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.