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SYSTEMATIC REVIEW article

Front. Genet.
Sec. Applied Genetic Epidemiology
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1434975

Association between haptoglobin polymorphism and coronary artery disease: a meta-analysis

Provisionally accepted
Jiao Wang Jiao Wang Xiaokai Zhou Xiaokai Zhou Yue Su Yue Su Dongjian Chai Dongjian Chai Yaoyao Ruan Yaoyao Ruan Jinhua Wang Jinhua Wang *
  • Quzhou City People's Hospital, Quzhou, China

The final, formatted version of the article will be published soon.

    Background Previous studies have investigated the association between the haptoglobin rs72294371 polymorphism and coronary artery disease (CAD) risk, but the results are controversial and uncertain. Therefore, this study aimed to systematically review the literature on haptoglobin polymorphism and susceptibility to CAD. Methods PubMed, Embase, Web of Science, Cochrane Library, and Wanfang databases were used to identify relevant studies from their inception to April 2024. The pooled odds ratio (OR) with corresponding 95 % confidence interval (CI) were used to assess the strength of the association. An OR value greater than one suggested an increased risk; otherwise, it suggested a protective risk.Results A total of 15 studies comprising 8632 individuals (2988 cases and 5644 controls) were included. In the current meta-analysis, a significant association between haptoglobin polymorphism and CAD was found under recessive model (OR:0.74, 95% CI:0.60-0.92), dominant model (OR: 0.82, 95% CI: 0.71-0.95), homozygote model (OR: 0.70, 95% CI: 0.53-0.92), and allelic genetic model (OR: 0.80, 95% CI: 0.69-0.94). In the analysis stratified by ethnicity, a statistically significant association was observed in Asians rather than Caucasian population.This meta-analysis indicates that haptoglobin polymorphism is associated with CAD susceptibility, especially in Asians.

    Keywords: Coronary Artery Disease, Haptoglobin, polymorphism, Meta-analysis, susceptibility

    Received: 20 May 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Wang, Zhou, Su, Chai, Ruan and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jinhua Wang, Quzhou City People's Hospital, Quzhou, 324000, China

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