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ORIGINAL RESEARCH article

Front. Genet.
Sec. Human and Medical Genomics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1434681
This article is part of the Research Topic High-throughput Sequencing-based Investigation of Chronic Disease Markers and Mechanisms, Volume II View all 7 articles

GWAS-significant loci and severe COVID-19: analysis of associations, link with thromboinflammation syndrome, gene-gene, and gene-environmental interactions

Provisionally accepted
Alexey V. Loktionov Alexey V. Loktionov 1Ksenia A. Kobzeva Ksenia A. Kobzeva 1Andrey R. Karpenko Andrey R. Karpenko 1Vera A. Sergeeva Vera A. Sergeeva 1Yuriy L. Orlov Yuriy L. Orlov 2*Olga Y. Bushueva Olga Y. Bushueva 1*
  • 1 Kursk State Medical University, Kursk, Kursk Oblast, Russia
  • 2 I.M. Sechenov First Moscow State Medical University, Moscow, Moscow Oblast, Russia

The final, formatted version of the article will be published soon.

    The aim of this study was to replicate associations of GWAS-significant loci with severe COVID-19 in the population of Central Russia, to investigate associations of the SNPs with thromboinflammation parameters, to analyze gene-gene and gene-environmental interactions.Materials and methods: DNA samples from 798 unrelated Caucasian subjects from Central Russia (199 hospitalized COVID-19 patients and 599 controls with a mild or asymptomatic course of COVID-19) were genotyped using probe-based PCR for 10 GWAS-significant SNPs: rs143334143

    Keywords: chronic diseases, genotyping, COVID-19, GWAS, thromboinflammation syndrome, rs17713054, rs17078346, rs12610495

    Received: 18 May 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Loktionov, Kobzeva, Karpenko, Sergeeva, Orlov and Bushueva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuriy L. Orlov, I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Moscow Oblast, Russia
    Olga Y. Bushueva, Kursk State Medical University, Kursk, 634003, Kursk Oblast, Russia

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