AUTHOR=Vázquez-Pérez Luis Alberto , Hattori-Hara Mónica , Arankowsky-Sandoval Gloria , Pérez-Mendoza Gerardo , Rubi-Castellanos Rodrigo , Rangel-Méndez Jorge Aarón , Pinto-Escalante Doris , Canto-Cetina Thelma , González-Herrera Lizbeth 

TITLE=Association between personality traits, eating behaviors, and the genetic polymorphisms FTO-rs9939609 and MAO-A 30 bp u-VNTR with obesity in Mexican Mayan children

JOURNAL=Frontiers in Genetics

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1421870

DOI=10.3389/fgene.2024.1421870

ISSN=1664-8021

ABSTRACT=<sec><title>Introduction</title><p>Genetic variants that control dopamine have been associated with obesity in children through loss of control of satiety and impulses, the manifestation of addictive eating behaviors, and specific personality traits. The variants include <italic>FTO</italic>-rs9939609 and the <italic>MAO-A</italic> 30 pb u-VNTR low-transcription alleles (LTA).</p></sec><sec><title>Objective</title><p>To evaluate the genetic association of <italic>FTO</italic>-rs9939609 and the <italic>MAO-A</italic> LTA, along with personality traits and eating behavior with obesity in Mayan children from Mexico.</p></sec><sec><title>Methods</title><p>We cross-sectionally evaluated 186 children (70 with obesity and 116 with normal weight) 6–12 years old from Yucatan, Mexico. Nutritional status was defined with body mass index (BMI) percentiles. Personality traits were evaluated with the Conners and TMCQ tests; eating behavior was evaluated with the CEBQ test. Genotyping with real-time PCR and TaqMan probes was used for <italic>FTO</italic>-rs9939609, whereas PCR amplification was used for <italic>MAO-A</italic> u-VNTR.</p></sec><sec><title>Results</title><p>High-intensity pleasure (<italic>p</italic> = 0.013) and moderate appetite (<italic>p</italic> = 0.032) differed according to nutritional status. Heterozygous <italic>FTO</italic>-rs9939609 T/A children showed higher mean scores of low-intensity pleasure (<italic>p</italic> = 0.002) and moderate appetite (<italic>p</italic> = 0.027) than homozygous T/T. Hemizygous boys having <italic>MAO-A</italic> LTA showed significantly higher mean scores of anxiety (<italic>p</italic> = 0.001) and impulsivity (<italic>p</italic> = 0.008). In multivariate models, only LTA alleles of <italic>MAO-A</italic> explained obesity in boys (OR = 4.44; 95% CI = 1.18–16.63).</p></sec><sec><title>Conclusion</title><p>In the present study, <italic>MAO-A</italic> u-VNTR alleles were associated with obesity in multivariate models only in boys. These alleles might also have a role in personality traits such as anxiety and impulsivity, which secondly contribute to developing obesity in Mayan boys.</p></sec>