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REVIEW article

Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1417415
This article is part of the Research Topic Dissection of Molecular Mechanisms and Novel Biomarkers of Breast Cancer Using Single-Cell Sequencing and Spatial Transcriptome View all 3 articles

Recent Progress and Applications of Single-Cell Sequencing Technology in Breast Cancer

Provisionally accepted
Basmah Khoja Basmah Khoja Abdullah O. Aljaylani Abdullah O. Aljaylani Raniah Jaha Raniah Jaha Huda Al Numan Huda Al Numan Mohammed I. Khan Mohammed I. Khan Yousef M. Hawsawi Yousef M. Hawsawi *
  • Research Center, King Faisal Specialist Hospital and Research Center, Jeddah 21499, P.O. Box 40047, Saudi Arabia

The final, formatted version of the article will be published soon.

    Abstract Single-cell RNA sequencing (scRNA-seq) technology enables the precise analysis of individual cell transcripts with high sensitivity and throughput. When integrated with multiomics technologies, scRNA-seq significantly enhances the understanding of cellular diversity, particularly within the tumor microenvironment. Similarly, single-cell DNA sequencing has emerged as a powerful tool in cancer research, offering unparalleled insights into the genetic heterogeneity and evolution of tumors. In the context of breast cancer, this technology holds substantial promise for decoding the intricate genomic landscape that drives disease progression, treatment resistance, and metastasis. By unraveling the complexities of tumor biology at a granular level, single-cell DNA sequencing provides a pathway to advancing our comprehension of breast cancer and improving patient outcomes through personalized therapeutic interventions. As single-cell sequencing technology continues to evolve and integrate into clinical practice, its application is poised to revolutionize the diagnosis, prognosis, and treatment strategies for breast cancer. This review explores the potential of single-cell sequencing technology to deepen our understanding of breast cancer, highlighting key approaches, recent advancements, and the role of the tumor microenvironment in disease plasticity. Additionally, the review discusses the impact of single-cell sequencing in paving the way for the development of personalized therapies.

    Keywords: single-cell sequencing, breast cancer, tumor heterogeneity, microenvironment, personalized therapy

    Received: 14 Apr 2024; Accepted: 05 Sep 2024.

    Copyright: © 2024 Khoja, Aljaylani, Jaha, Al Numan, Khan and Hawsawi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yousef M. Hawsawi, Research Center, King Faisal Specialist Hospital and Research Center, Jeddah 21499, P.O. Box 40047, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.