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REVIEW article

Front. Genet.
Sec. Applied Genetic Epidemiology
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1416924

Genetic Insights and Emerging Therapeutics in Diabetic Retinopathy: From Molecular Pathways to Personalized Medicine

Provisionally accepted
Xiaoting Pei Xiaoting Pei Zhijie Li Zhijie Li *
  • Henan Provincial People's Hospital, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Diabetic retinopathy (DR) is a major complication of diabetes worldwide, significantly causing vision loss and blindness in working-age adults, and imposing a substantial socioeconomic burden globally. This review examines the crucial role of genetic factors in the development of DR and highlights the shift toward personalized treatment approaches. Advances in genetic research have identified specific genes and variations involved in angiogenesis, inflammation, and oxidative stress that increase DR susceptibility. Understanding these genetic markers enables early identification of at-risk individuals and the creation of personalized treatment plans.Incorporating these genetic insights, healthcare providers can develop early intervention strategies and tailored treatment plans to improve patient outcomes and minimize side effects. This review emphasizes the transformative potential of integrating genetic information into clinical practice, marking a paradigm shift in DR management and advancing toward a more personalized and effective healthcare model.

    Keywords: Diabetic Retinopathy, Genetic Susceptibility, personalized treatment, Genetic variations, Gene Therapy

    Received: 13 Apr 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Pei and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhijie Li, Henan Provincial People's Hospital, Zhengzhou, 450000, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.